PEN-Cur is one of the most PHARMACOKINETIC curcumin supplements around...
345x more of free curcumin in blood plasma (1*)
9x better absorption than piperine added formulas (2*)
50x higher antioxidant activity (3*)
8x greater sustained free curcumin release (1*)
PEN-Cur's Bioavailability & Metabolism
High bioavailability and the steady release of free curcumin into the blood (6-8 hours) is the most important quality of PEN-Cur's unique formula, and it has been developed through innovative
encapsulating technology utilising natural non-toxic biodegradable edible polymer nano-capsules.
PEN-Cur shows a 345-fold higher absorption rate than compared to normal curcumin supplements being sold in the market, according to a study (1*).
Pre-clinical pharmacokinetics revealed that polymer encapsulated nano curcumin demonstrated at least a 9-fold increase in oral bioavailability when compared to curcumin administered with piperine as an absorption enhancer, currently being sold in the market.
PEN-Cur's nano curcumin particles are smaller than bacteria, viruses and red blood cells.
(1*) Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc™) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther. 2010 Aug; 9(8): 2255–2264. PMCID: PMC2942082, NIHMSID: NIHMS231506 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942082/)
2) Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. European Journal of Pharmaceutical Sciences, Volume 37, Issues 3–4, 28 June 2009, Pages 223–230 (http://www.sciencedirect.com/science/article/pii/S0928098709000621)
3) Evolution of availability of curcumin inside poly-lactic-co-glycolic acid nanoparticles: impact on antioxidant and antinitrosant properties. PMC full text:Int J Nanomedicine. 2015; 10: 5355–5366. Published online 2015 Aug 26. doi: 10.2147/IJN.S84760 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554401/)